Hypocalcaemia, long QT interval and atrial arrhythmias

[The long QT interval syndrome].

The syndrome of long QT interval frequently follows to syncope or a sudden cardiac death on the basis of originated polymorphic ventricular tachycardia of the "torsade de pointes" type. The prolongation of the QT interval in the hereditary form is based on mutation of the genes responsible for the formation of sodium and potassium channels. The authors analyze the occurrence, clinical findings,...

The QT interval in atrial fibrillation.

The electrocardiogram was recorded for 100 seconds in 50 patients with atrial fibrillation to determine the relations between QT intervals and both the mean and instantaneous ventricular rates. The mean ventricular rate was 94 beats per minute with a mean QT interval of 357 ms. The mean QTc, corrected beat by beat with Bazett's formula, was 444 ms--longer than reported for sinus rhythm. Between...

Polymorphisms in the NOS1AP gene modulate QT interval duration and risk of arrhythmias in the long QT syndrome.

OBJECTIVES We investigated the role of nitric oxide 1 adaptor protein (NOS1AP) as a genetic modifier of long QT syndrome (LQTS). BACKGROUND LQTS risk stratification is complicated by the phenotype variability that limits prediction of life-threatening arrhythmic events based on available metrics. Thus, the identification of new markers is desirable. Recent studies have shown that NOS1AP varia...

QT Interval and QT Variability

[Atrial fibrillation in the long QT syndrome].

A case of a 58-year-old woman with occasionally diagnosed persistent atrial fibrillation (AF) is presented. The patient for many years experienced palpitations relived by oral propranolol treatment. After electrical cardioversion of AF to sinus rhythm prolongation of the QTc interval up to 520 ms became evident. Molecular screening of LQTS-related genes revealed the presence of R231S mutation i...